H. Lee Moffitt Cancer Center & Research Institute

MARCH/APRIL 2003

Vol 10, No 2 CME Pretest

In this issue, the topic of neuro-oncology is addressed. First, answer the pretest questions below. After reading the articles, proceed with answering the CME posttest questions.

This Journal provides 4 hours of Category 1 Continuing Medical Education

Complimentary CME Credits

Physicians can earn 4 credit hours of Category 1 for the Physician's Recognition Award of the American Medical Association by reading the material in this issue and successfully answering the questions in the posttest at the end of this issue. Complete instructions are given on the posttest pages. Successfully answering 30 or more questions will earn 4 credit hours.

Educational Objectives

After reading this issue of Cancer Control, clinicians will be expected to:

  • understand the role of intraoperative imaging during surgery for gliomas,
  • appreciate the value of complete resection of gliomas,
  • discuss the biology behind immunotherapy and small molecular approaches to brain tumor therapy,
  • be aware of current approaches to managing recurrent meningiomas, and
  • describe the status of research in minimizing multidrug resistance.

This program was planned in accordance with ACCME Essentials.

Release Date: March 1, 2003
Expiration Date: March 1, 2004


Pretest

1. Sawaya et al performed volumetric analysis of glioma to determine the extent of resection of glioma.  In patients under 45 years of age with a Karnofsky score above 80 and with no necrosis on MRI scan, the median survival of the entire group was 32.8 months.  What was the median survival for the patients who had ≥98% resection?

a. 27.9 months
b. 35.3 months
c. 44.2 months
d. 60.4 months

2. Overexpression or mutations in the epidermal growth factor receptor occurs in what proportion of glioblastoma multiforme tumors?

a. 95%
b. 70%
c. 50%
d. 30%

3. What is the dominant mechanism of action of hydroxyurea?

a. inhibits DNA synthesis
b. inhibits RNA synthesis
c. inhibits protein synthesis
d. poisons microtubiles




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